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Year Number of Results
1988 1
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1995 5
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1997 9
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1999 4
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2002 5
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156 results

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Page 1
Metabolic stress, IAPP and islet amyloid.
Montane J, Klimek-Abercrombie A, Potter KJ, Westwell-Roper C, Bruce Verchere C. Montane J, et al. Diabetes Obes Metab. 2012 Oct;14 Suppl 3:68-77. doi: 10.1111/j.1463-1326.2012.01657.x. Diabetes Obes Metab. 2012. PMID: 22928566 Review.
Amyloid forms within pancreatic islets in type 2 diabetes from aggregates of the beta-cell peptide islet amyloid polypeptide (IAPP). These aggregates are toxic to beta-cells, inducing beta-cell death and dysfunction, as well as inciting islet …
Amyloid forms within pancreatic islets in type 2 diabetes from aggregates of the beta-cell peptide islet amyloid pol …
Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3beta and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease.
Thota RN, Rosato JI, Dias CB, Burrows TL, Martins RN, Garg ML. Thota RN, et al. Nutrients. 2020 Apr 9;12(4):1032. doi: 10.3390/nu12041032. Nutrients. 2020. PMID: 32283762 Free PMC article. Clinical Trial.
Plasma samples from participants recruited for a randomised controlled trial with curcumin (180 mg/day) for 12 weeks were analysed for circulating glycogen synthase kinase-3 beta (GSK-3beta) and islet amyloid polypeptide (IAPP). Outcome measures were d …
Plasma samples from participants recruited for a randomised controlled trial with curcumin (180 mg/day) for 12 weeks were analysed for circu …
IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).
Karlsson E. Karlsson E. Int J Mol Med. 1999 Jun;3(6):577-84. doi: 10.3892/ijmm.3.6.577. Int J Mol Med. 1999. PMID: 10341286 Review.
Despite co-secretion from islets the relative amounts of IAPP and insulin may vary. Since IAPP was first described as the major peptide constituent of amyloid in the islets of Langerhans of subjects with type 2 diabetes and insulinoma, many studies have been …
Despite co-secretion from islets the relative amounts of IAPP and insulin may vary. Since IAPP was first described as the majo …
Childhood obesity: a systems medicine approach.
Stone WL, Schetzina K, Stuart C. Stone WL, et al. Front Biosci (Landmark Ed). 2016 Jun 1;21(5):1061-75. doi: 10.2741/4441. Front Biosci (Landmark Ed). 2016. PMID: 27100491 Free article. Review.
Insulin Signal Transduction Perturbations in Insulin Resistance.
Khalid M, Alkaabi J, Khan MAB, Adem A. Khalid M, et al. Int J Mol Sci. 2021 Aug 10;22(16):8590. doi: 10.3390/ijms22168590. Int J Mol Sci. 2021. PMID: 34445300 Free PMC article. Review.
The interplay of inflammation and oxidative stress that leads to beta-cell decline through the IAPP-RAGE induced beta-cell toxicity is also addressed. Overall, by generating a comprehensive overview of the plethora of mechanisms involved in insulin resistance, we focus on …
The interplay of inflammation and oxidative stress that leads to beta-cell decline through the IAPP-RAGE induced beta-cell toxicity i …
[Amylin/IAPP (islet amyloid polypeptide)--physiology and clinical significance].
Ludvik B. Ludvik B. Wien Klin Wochenschr. 1997 Jun 6;109(11):379-83. Wien Klin Wochenschr. 1997. PMID: 9281227 Review. German.
Amylin or islet amyloid polypeptide (IAPP) is the protein component of amyloid deposits commonly seen in pancreatic islets of patients with type 2 diabetes mellitus. ...
Amylin or islet amyloid polypeptide (IAPP) is the protein component of amyloid deposits commonly seen in …
Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy.
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H. Shigihara N, et al. J Clin Invest. 2014 Aug;124(8):3634-44. doi: 10.1172/JCI69866. Epub 2014 Jul 18. J Clin Invest. 2014. PMID: 25036706 Free PMC article.
Pancreatic islets in patients with type 2 diabetes mellitus (T2DM) are characterized by loss of beta cells and formation of amyloid deposits derived from islet amyloid polypeptide (IAPP). Here we demonstrated that treatment of INS-1 cells with h …
Pancreatic islets in patients with type 2 diabetes mellitus (T2DM) are characterized by loss of beta cells and formation of amyloid d …
156 results